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    nanoscience and nanotechnology: small is different

Prof. Angeles Villanueva Oroquieta

Position: Associate Research Professor
PhD: Universidad Autónoma de Madrid, Spain
Double Affiliation: Universidad Autónoma de Madrid, Spain
Research: Magnetic Nanoparticles in Biomedicine. Cell-Particle Interaction
Joining Date: January, 2010
User Name: angeles.villanueva
Telephone: +34 91 299 88 61
Villanueva Oroquieta

Dr. Angeles Villanueva is a cell biologist. Her research is mainly focused on photodynamic therapy of cancer. In the last years, she has established new collaborations with research groups in the field of mag- netic nanoparticles with applications in Medicine. She has stud ied in cell cultures: i) the mechanisms of nanoparticles internalization; ii) their subcellular localization; iii) the nano- particles biocompatibility; and iv) the identification the cell death mechanism induced by heatcontrolled intracellular hyperthermia with magnetic nanoparti- cles and an alternating magnetic field.

Research Lines

  • Medical applications of nanoparticles.
  • Cell cultures. 
  • Biocompatibilty of magnetic nanoparticles. 
  • Mechanisms of cell death. 
  • Alterations in adhesion and cytoskeletal proteins. 
  • Liposomal drug delivery. 
  • Evaluation in cell cultures and in vivo experimental models of new antitumor agents. 
  • Signaling pathways involved in cell death.

Relevant publications

  • “Photodynamic effects on culure tumor cells. Cytoskeleton alterations and cell death mechanisms” Villanueva A. et. col In Handbook of Photochemistry and Photobiology. Vol: 4, pp: 79-117. 2003. (Ed. H. S. Nalwa). American Scientific Publisher. California, USA
  • “Morphological criteria to distinguish cell death induced by apoptotic and necrotic treatments” Rello S., et col. Apoptosis 10: 201-8, 2005
  • “The influence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cells” Villanueva A., et col. Nanotechnology 20: 115103-115111, 2009