Intracellular Temperature Measurements

The Thompson Laboratory focuses on advancing nanoscale thermometry to explore temperature dynamics within biological systems, particularly in cancer research. Using cutting-edge optical techniques—such as fluorescence anisotropy, luminescence, and photonic probes—the group develops innovative nanothermometers capable of measuring temperature with subcellular precision. Their work pioneers both intracellular and extracellular temperature sensing, including strategies that transform endogenous proteins and clinically approved dyes into temperature-sensitive reporters.

Recent studies also investigate how localized light irradiation can disrupt the plasma membrane, enabling controlled cell death through photodynamic or hyperthermic mechanisms. Uniquely, every experimental project is complemented by theoretical modeling to refine the interpretation of results and guide future clinical applications. Overall, the Thompson Lab integrates nanotechnology, biophotonics, theoretical simulations, and cancer biology to uncover how thermal microenvironments influence cellular processes and to harness these effects for therapeutic innovation